Researchers may have found ways to slow ovarian aging by using inexpensive immunosuppressants commonly used to treat tumors and kidney transplant patients.
A new small-scale study conducted at Columbia University. Professor Yushin Su and Associate Professor Zev Williams co-led with the This drug was found to expand fertility, delay menopause, and improve the risk of women with age-related diseases. As a result, this drug can reduce ovarian aging by 20%.
The findings are exciting for many. Because women want to be able to increase their chances of fertility.
Side effects in people using rapamycin are hypertension, infection, headache and nausea, but women in the study using rapamycin for their fertility did not experience these side effects. This means that the lifespan of the ovaries can be extended without spending comfort in women.
Women included in the randomized placebo-controlled study self-reported their improvement. They claimed that their energy levels, memory, skin and hair all improved during rapamycin. a Research preprint Women, including 40 women, were found to increase the mass of lean tissue and improve the quality of life associated with pain and social function when participants took 10 mg of rapamycin each week.
Rapamycin helps with fertility in several ways. This drug can improve the outcome of in vitro fertilization (IVF) in women with endometriosis. It can also improve the quality of eggs discovered in a 2022 study involving mice and humans. Clinical trials of rapamycin are primarily performed in mice, as they take decades to reveal life-related outcomes. However, the ovaries age at a fast rate, making the results easy to measure.
So how does rapamycin increase fertility?
Rapamycin inhibits mechanical targets of the rapamycin (mTOR) pathway. This is essential for cell growth and survival. This means that inhibition slows cell aging.
Participants in this study were entitled Validation Benefits of Rapamycin for Reproductive Aging Treatment (Vivid), taking small doses of rapamycin (5 mg) for 3 months, and the ovaries released fewer eggs. Patients who have undergone transplant usually take 13 mg of rapamycin per day.
It is important to know how much rapamycin a person takes. Too much dosage can actually stop ovulation completely.
Women are born with millions of eggs, but as they age, the number of eggs decreases and the quality of the eggs decreases. Women usually lose 50 eggs a month, and ovaries are the fastest aging organ in the female body, so ovarian aging is essential for fertility.
In this study, rapamycin reduced the loss of 50 eggs per month to 15 eggs per month. This means that the amount of ovaries a woman has is preserved, increasing the likelihood of pregnancy. In addition to rapamycin, it is difficult to naturally increase your fertility. Certain lifestyle changes can ensure the health and quality of the eggs.
For those looking to conceive, a balanced, nutritious diet is key. Women should aim to:
- Omega-3 fatty acids found in fish, flaxseeds, and walnuts.
- Vitamin D from sunlight, fatty fish and dairy products.
- Vitamin C and E found in fruits, vegetables and nuts.
- Iron found in meat and beans.
- Protein found in lean meat, beans and legumes.
Additionally, women looking to conceive can take supplements due to egg quality. Like:
- Vitamin B6 for hormone regulation.
- Hormonally produced zinc.
- Fertility probiotics.
- Prenatal supplements for reproductive health.
Other factors include regular exercise, managing stress, avoiding smoking and alcohol, and maintaining a healthy weight.
This research is still underway. He hopes that by the time the trial ends, there will be 1,000 participants. They plan to complete the study in two years.
Rapamycin is already widely available, but the US Food and Drug Administration has not approved it for treatment of menopause, fertility, or lifespan. It is unclear if or if it will be available as a fertility treatment. However, future phase 3 exams should be promising.
